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                CD68 Mouse mAb
                EM1050
                規格: 價格:
                50 μl ¥1280.00
                100 μl ¥1980.00

                Overview

                Product name: CD68 Mouse mAb
                Human Swiss-Prot No.: P34810
                Reactivity: Human, Rat, Mouse
                Alternative Names: CD68 molecule, GP110, Macrosialin, SCARD1
                Source: Mouse
                Applications : IHC
                Species reactivity: Human, Rat, Mouse
                Species: Human
                Recommended dilutions: IHC 1:200
                Immunogen: Synthetic Peptide
                Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
                Clonality: Monoclonal
                Isotype: IgG1
                Concentration: 1mg/ml
                Observed band: 37kDa
                GeneID(Human): 968
                Cellular localization: Cell membrane and Endosome membrane. Lysosome membrane
                Background: The CD68 antigen is a 37kD transmembrane protein that is post-translationally glycosylated to give a protein of 87-115kD. CD68 is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells.
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